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For weight loss and metabolism Semaglutide (GLP-1 agonist) - #1 for menopausal weight: Why it's best: Directly addresses insulin resistance common after 40 Reduces appetite dramatically 15-20% body weight loss typical Works when diet/exercise alone fail FDA-approved for weight loss Dosing for women 40+: Start: 0.25mg weekly Titrate slowly to 1-2.4mg over 16-20 weeks Weekly injection subcutaneous 3-6+ months for best results Timeline: Month 1: Appetite reduction begins Month 2-3: 10-15 lbs lost Month 4-6: 20-30 lbs lost (if needed) Maintain: Lower dose ongoing Use our semaglutide dosage calculator and see semaglutide vs tirzepatide comparison